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Nucleic Acids Research, 1992, Vol. 20, No. 11 2827-2834
© 1992

MOLECULAR BIOLOGY

Zfp-37, a new murine zinc finger encoding gene, is expressed in a developmentally regulated pattern in the male germ line

Patrick S. Burke1 and Debra J. Wolgemuth1,2,3,*

1Departments of Genetics and Development, 630 West 168th Street, New York, NY 10032, USA 2Obstetrics and Gynecology 630 West 168th Street, New York, NY 10032, USA 3The Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons 630 West 168th Street, New York, NY 10032, USA

*To whom correspondence should be addressed at Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA

Received February 5, 1992. Revised April 24, 1992. Accepted April 24, 1992.

To begin to examine the function in the mouse testis of genes containing the zinc finger motif, we have screened an adult mouse total testis cDNA library with probes to a conserved region of zinc fingers. We have isolated cDNAs for a new murine zinc finger encoding gene that has been designated Zfp-37. Northern blot hybridization analysis revealed Zfp-37 transcripts at high levels in the testis, the only adult tissue in which Zfp-37 expression was observed. Zfp-37 was also expressed at lower levels in the mid-gestation embryo and placenta. The major testicular transcripts are 2.3 and 2.6 kb. A 4.0 kb transcript was detected at lower levels in the testis as well as in embryo and placenta. Northern blot and in situ hybridization analysis revealed that expression of Zfp-37 was most abundant in germ cells which have completed meiosis and are undergoing the complex morphogenetic changes of spermiogenesis. The pattern of expression of Zfp-37 and the presence of the zinc finger domain suggest that Zfp-37 may have a role in regulating spermiogenesis.


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