Nucleic Acids Research, 1992, Vol. 20, No. 2 225-229
© 1992
MOLECULAR BIOLOGY |
Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation
Laboratory of Radiobiology and Environmental Health, University of California San Francisco, CA 94143-0750, USA
*To whom correspondence should be addressed at University of Texas, M.D. Anderson Cancer Center, Science Park/Research Division, Smithville, TX 78957, USA
Received November 5, 1991. Revised November 26, 1991. Accepted November 26, 1991.
Cyclobutane pyrimidine dimers were quantified at the sequence level after irradiation with solar ultraviolet (UVB) and nonsolar ultraviolet (UVC) light sources. The yield of photoproducts at specific sites was dependent on the nucleotide composition in and around the potential lesion as well as on the wavelength of ultraviolet light used to induce the damage. Induction was greater in the presence of 5' flanking pyromidines than purines; 5' guanine inhibited induction more than adenine. UVB irradiation increased the induction of cyclobutane dimers containing cytosine relative to thymine homodimers. At the single UVC and UVB fluences used, the ratio of thymine homodimers (T< >T) to dimers containing cytosine (C< >T, T< >C, C< >C) was greater after UVC compared to UVB irradiation.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Molinier, G. Ries, S. Bonhoeffer, and B. Hohn Interchromatid and Interhomolog Recombination in Arabidopsis thaliana PLANT CELL, February 1, 2004; 16(2): 342 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Kozmin, Y. I. Pavlov, T. A. Kunkel, and E. Sage Roles of Saccharomyces cerevisiae DNA polymerases Pol{eta} and Pol{zeta} in response to irradiation by simulated sunlight Nucleic Acids Res., August 1, 2003; 31(15): 4541 - 4552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Rochette, J.-P. Therrien, R. Drouin, D. Perdiz, N. Bastien, E. A. Drobetsky, and E. Sage UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells Nucleic Acids Res., June 1, 2003; 31(11): 2786 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-H. Lee and G. P. Pfeifer Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB Mutagenesis J. Biol. Chem., March 21, 2003; 278(12): 10314 - 10321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Mahroos, M. Yaar, T. J. Phillips, J. Bhawan, and B. A. Gilchrest Effect of Sunscreen Application on UV-Induced Thymine Dimers Arch Dermatol, November 1, 2002; 138(11): 1480 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. MICHALOVA, R. CLEMETT, A. DEMPSTER, J. EVANS, and R. A ALLARDYCE Iris melanomas: are they more frequent in New Zealand? Br. J. Ophthalmol., January 1, 2001; 85(1): 4 - 5. [Full Text]
|
|
|
|
 |
|
 D. GOUKASSIAN, F. GAD, M. YAAR, M. S. ELLER, U. S. NEHAL, and B. A. GILCHREST Mechanisms and implications of the age-associated decrease in DNA repair capacity FASEB J, July 1, 2000; 14(10): 1325 - 1334. [Abstract] [Full Text]
|
|
|
|
|
|
A. O. Murad, J. de Cock, D. Brown, and M. J. Smerdon Variations in Transcription-Repair Coupling in Mouse Cells J. Biol. Chem., February 24, 1995; 270(8): 3949 - 3957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Perdiz, P. Grof, M. Mezzina, O. Nikaido, E. Moustacchi, and E. Sage Distribution and Repair of Bipyrimidine Photoproducts in Solar UV-irradiated Mammalian Cells. POSSIBLE ROLE OF DEWAR PHOTOPRODUCTS IN SOLAR MUTAGENESIS J. Biol. Chem., August 25, 2000; 275(35): 26732 - 26742. [Abstract] [Full Text] [PDF]
|
|