Skip Navigation

This Article
Right arrow Print PDF (560K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (33)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Chen, Y.Z.
Right arrow Articles by Prohofsky, E. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, Y.Z.
Right arrow Articles by Prohofsky, E. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1992, Vol. 20, No. 3 415-419
© 1992

CHEMISTRY

The role of a minor groove spine of hydration in stabilizing poly(dA). poly(dT) against fuctuational interbase H-bond disruption in the premelting temperature regime

Y.Z. Chen and E. W. Prohofsky

Department of Physics, Purdue University West Lafayette, IN 47907, USA

Received November 15, 1991. Revised February 7, 1992. Accepted February 7, 1992.

Experimental estimates of the premelting Adenine-Thymine base pair opening probability for some B-BNA sequences are two orders of magnitude smaller than those of other B-BNA sequences. The AT pairs in the sequence with smaller open probability seem to be those that have a well defined spine of hydration in the minor groove. We show that this spine of hydration can significantly enhance the thermal stability of the base pairs to which they are attached. The effect of this spine of hydration coupled with the possible stabilization effect contributed from neighboring GC pairs can explain the the differences in the observed AT pair opening probability for different AT containing sequences.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
Z. W. Cao, Y. Xue, L. Y. Han, B. Xie, H. Zhou, C. J. Zheng, H. H. Lin, and Y. Z. Chen
MoViES: molecular vibrations evaluation server for analysis of fluctuational dynamics of proteins and nucleic acids
Nucleic Acids Res., July 1, 2004; 32(suppl_2): W679 - W685.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. Madhumalar and M. Bansal
Structural Insights into the Effect of Hydration and Ions on A-Tract DNA: A Molecular Dynamics Study
Biophys. J., September 1, 2003; 85(3): 1805 - 1816.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. M. Ababneh, C. C. Large, and S. Georghiou
Solvation of Nucleosides in Aqueous Mixtures of Organic Solvents: Relevance to DNA Open Basepairs
Biophys. J., August 1, 2003; 85(2): 1111 - 1127.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.