Nucleic Acids Research, 1992, Vol. 20, No. 8 1967-1972
© 1992
MOLECULAR BIOLOGY |
Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3
Department of Neoplastic Diseases, Hahnemann University Philadelphia, PA 19102–1192, USA
*To whom correspondence should be addressed
Received December 27, 1991. Revised March 8, 1992. Accepted March 8, 1992.
A gene encoding a putative human RNA hellcase, p54, has been cloned and mapped to the band q23.3 of chromosome 11. The predicted amino acid sequence shares a striking homology (75% identical) with the female germ line-specific RNA hellcase ME31B gene of Drosophila. Unlike ME31B, however, the new gene expresses an abundant transcript in a large number of adult tissues and its 5' non-coding region was found split in a t(11; 14)(q23.3;q32.3) cell line from a diffuse large B-cell lymphoma.
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