Nucleic Acids Research, 1994, Vol. 22, No. 15 3104-3112
© 1994
MOLECULAR BIOLOGY |
An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae
Department of Biology, Faculty of Science, Osaka University 1-1 Machikaneyama-cho, Toyonaka, Osaka 560, Japan
* To whom correspondence should be addressed
Received April 25, 1994. Revised May 31, 1994. Accepted May 31, 1994.
A new mutant, which was sensitive to both methylmethanesulfonate (MMS) and ultra-violet light (UV) and defective in meiotic recombination, was isolated from Saccharomyces cerevisiae. The gene, ESR1, was cloned by complementation of the MMS sensitivity of the mutant and found to be essential for cell growth, as the deleted haploid strain was lethal. The ESR1 gene was adjacent to the CKS1 gene on chromosome II and encoded a putative 2368-amino acid protein with a molecular weight of 273 k. The ESR1 transcript was 8.0 kb long and was induced during meiosis. The predicted Esr1 protein had a mosaic structure composed of homologous regions and showed amino acid sequence similarities to Schizosaccharomyces pombe rad3+ protein, which monitors completion of DNA repair synthesis, and cut1+ protein, which is required for spindle pole body (SPB) duplication. The Esr1 protein was also similar to phosphatidylinositol (PI) 3-kinases, including Saccharomyces cerevisiae T0R2 (and DRR1), which are involved in G1 progression. These results suggest that ESR1 is multi-functional throughout mitosis and meiosis.
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
A. E. Parker, I. Van de Weyer, M. C. Laus, P. Verhasselt, and W. H. M. L. Luyten Identification of a Human Homologue of the Schizosaccharomyces pombe rad17+ Checkpoint Gene J. Biol. Chem., July 17, 1998; 273(29): 18340 - 18346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
H. D. Lindsay, D. J.F. Griffiths, R. J. Edwards, P. U. Christensen, J. M. Murray, F. Osman, N. Walworth, and A. M. Carr S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe Genes & Dev., February 1, 1998; 12(3): 382 - 395. [Abstract] [Full Text]
|
|
|
|
 |
|
 C Barlow, M Liyanage, P. Moens, M Tarsounas, K Nagashima, K Brown, S Rottinghaus, S. Jackson, D Tagle, T Ried, et al. Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I Development, January 10, 1998; 125(20): 4007 - 4017. [Abstract] [PDF]
|
|
|
|
|
|
X.-F. Zheng and S. L. Schreiber Target of rapamycin proteins and their kinase activities are required for meiosis PNAS, April 1, 1997; 94(7): 3070 - 3075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Brush, D. M. Morrow, P. Hieter, and T. J. Kelly The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast PNAS, December 24, 1996; 93(26): 15075 - 15080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Elledge Cell Cycle Checkpoints: Preventing an Identity Crisis Science, December 6, 1996; 274(5293): 1664 - 1672. [Abstract] [Full Text]
|
|
|
|
|
|
T A Navas, Y Sanchez, and S J Elledge RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes & Dev., October 15, 1996; 10(20): 2632 - 2643. [Abstract] [PDF]
|
|
|
|
|
|
R S Hawley and S H Friend Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53. Genes & Dev., October 1, 1996; 10(19): 2383 - 2388. [PDF]
|
|
|
|
|
|
Y Xu, T Ashley, E E Brainerd, R T Bronson, M S Meyn, and D Baltimore Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes & Dev., October 1, 1996; 10(19): 2411 - 2422. [Abstract] [PDF]
|
|
|
|
|
|
K S Keegan, D A Holtzman, A W Plug, E R Christenson, E E Brainerd, G Flaggs, N J Bentley, E M Taylor, M S Meyn, S B Moss, et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes & Dev., October 1, 1996; 10(19): 2423 - 2437. [Abstract] [PDF]
|
|
|
|
|
|
Z Sun, D S Fay, F Marini, M Foiani, and D F Stern Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes & Dev., February 15, 1996; 10(4): 395 - 406. [Abstract] [PDF]
|
|
|
|
 |
|
 M Le Romancer, S. Cosulich, S. Jackson, and P. Clarke Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts J. Cell Sci., January 12, 1996; 109(13): 3121 - 3127. [Abstract] [PDF]
|
|
|
|
 |
|
 R Rothstein and S Gangloff Hyper-recombination and Bloom's syndrome: microbes again provide clues about cancer. Genome Res., December 1, 1995; 5(5): 421 - 426. [PDF]
|
|
|
|
|
|
M. C. Lorenz and J. Heitman TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin J. Biol. Chem., November 17, 1995; 270(46): 27531 - 27537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Keith and S. L. Schreiber PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints Science, October 6, 1995; 270(5233): 50 - 50. [Abstract] [PDF]
|
|
|
|
|
|
K Savitsky, A Bar-Shira, S Gilad, G Rotman, Y Ziv, L Vanagaite, D. Tagle, S Smith, T Uziel, S Sfez, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase Science, June 23, 1995; 268(5218): 1749 - 1753. [Abstract] [PDF]
|
|
|
|
|
|
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