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Nucleic Acids Research, 1994, Vol. 22, No. 24 5332-5340
© 1994

Articles

The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs

Zoi Lygerou, Christine Conesa1, Pascale Lesage2, Robert N. Swanson1,+, Anny Ruet1, Marian Carlson2, André Sentenac1 and Bertrand Séraphin*,

EMBL Meyerhofstrasse 1, D-69117 Heidelberg, Germany 1Service de Biochimie et de Geéneétique Moleéculaire, Centre d'Etudes Nucleaire de Saclay F-91191 Gif sur Yvette Cedex, France 2Department of Genetics and Development and Institute of Cancer Research, Columbia University College of Physicians and Surgeons New York, NY 10032, USA

*To whom correspondence should be addressed

+Present address Cold Spring Harbor Laboratory. P0 Box 100, Cold Spring Harbor, NY 11724, USA

Received August 22, 1994. Accepted November 9, 1994.

While screening for genes that affect the synthesis of yeast snRNPs, we Identified a thermosensitive mutant that abolishes the production of a reporter snRNA at the non-permissive temperature. This mutant defines a new gene, named BDF1. In a bdf1-1 strain, the reporter snRNA synthesized before the temperature shift remains stable at the non-permissive temperature. This demonstrates that the BDF1 gene affects the synthesis rather than the stability of the reporter snRNA and suggests that the BDF1 gene encodes a transcription factor. BDF1 Is present in single copy on yeast chromosome XII, and Is important for normal vegetative growth but not essential for cell viability. bdf1 null mutants share common phenotypes with several mutants affecting general transcription and are defective In snRNA production. BDF1 encodes a protein of 687 amino-acids containing two copies of the bromodomaln, a motif also present in other transcription factors as well as a new conserved domain, the ET domain, also present in Drosophlla and human proteins.


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