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Nucleic Acids Research, 1994, Vol. 22, No. 3 453-456
© 1994

CHEMISTRY

Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers

Liang Zhou, Alan M. Morocho, Ban-chin Chen and Jack S. Cohen

Cancer Pharmacology Section, Pharmacology Department, Georgetown University Medical Center Washington, DC 20007, USA

*To whom correspondence should be addressed at: Cancer Pharmacology Section, GUMC, 4 Research Court, Rockville, MD 20850, USA

Received September 1, 1993. Accepted December 3, 1993.

We describe the synthesis and characterization of novel phosphorothloate-methylphosphonate backbone-modified ollgodeoxynucleotide co-polymers. These may have potential use as antlsense constructs.


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