Skip Navigation

This Article
Right arrow Print PDF (1816K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Sellem, C. H.
Right arrow Articles by Belcour, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sellem, C. H.
Right arrow Articles by Belcour, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1994, Vol. 22, No. 7 1135-1137
© 1994

MOLECULAR BIOLOGY

The in vivo use of alternate 3'-splice sites in group I introns

Carole H. Sellem* and Léon Belcour

Centre de Génétique Moléculaire, CNRS Gif-sur-Yvette, F91198 Cedex, France

*To whom correspondence should be addressed

Received January 31, 1994. Accepted March 3, 1994.

Alternative splicing of group I introns has been postulated as a possible mechanism that would ensure the translation of proteins encoded into intronic open reading frames, dlscontinous with the upstream exon and lacking an initiation signal. Alternate splice sites were previously depicted according to secondary structures of several group I introns. We present here strong evidence that, in the case of Podospora anserina nad1-l4 and cox1-I7 mitochondrial introns, alternative splicing events do occur in vivo. Indeed, by PCR experiments we have detected molecules whose sequence is precisely that expected if the predicted alternate 3'-splice sites were used.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
A. R. ROBART, N. K. MONTGOMERY, K. L. SMITH, and S. ZIMMERLY
Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis
RNA, May 1, 2004; 10(5): 854 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Landthaler and D. A. Shub
Unexpected abundance of self-splicing introns in the genome of bacteriophage Twort: Introns in multiple genes, a single gene with three introns, and exon skipping by group I ribozymes
PNAS, June 8, 1999; 96(12): 7005 - 7010.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.