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Nucleic Acids Research, 1994, Vol. 22, No. 8 1421-1428
© 1994

MOLECULAR BIOLOGY

Isolation and characterization of two replication-dependent mouse H1 histone genes

Yonghe Dong, Allen M. Sirotkin, Yih-Sheng Yang1, David T. Brown1, Donald B. Sittman1 and Arthur I. Skoultchi*

Department of Cell Biology, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461 1Department of Biochemistry, The University of Mississippi Medical Center Jackson, MS 39216, USA

*To whom correspondence should be addressed

Received January 3, 1994. Revised March 9, 1994. Accepted March 9, 1994.

Mice contain at least seven nonallelic forms of the H1 hlstones, including the somatic variants H1a-e and less closely related variants H1° and Hit. The mouse H1° and H1c (H1var.1) genes were isolated and characterized previously. We have now Isolated, sequenced and studied the expression properties of two additional mouse H1 genes, termed H1var.2 and H1var.3. Extensive amino acid and nucleotlde sequence comparisons were made between the two genes and other mammalian H1 histone genes. A high degree of nucleotlde sequence Identity was seen between the H1var.2, rat H1d and human H1b genes, even well beyond the coding region, indicating that these genes are likely homologues. Unlike the previously characterized mouse H1var.1 gene which produces both nonpolyadenylated and polyadenylated mRNAs, the H1var.2 and H1var.3 genes produce only typical, replication dependent, nonpolyadenylated mRNAs.


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