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Nucleic Acids Research, Vol 24, Issue 1 177-179, Copyright © 1996 by Oxford University Press

ARTICLES

MITOMAP: a human mitochondrial genome database

AM Kogelnik, MT Lott, MD Brown, SB Navathe and DC Wallace
Department of Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

We have developed a comprehensive database (MITOMAP) for the human mitochondrial DNA (mtDNA), the first component of the human genome to be completely sequenced [Anderson et al. (1981) Nature 290, 457-465]. MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations and their clinical characteristics, population associated variation, and gene- gene interactions. As increasingly larger regions of the human genome are sequenced and characterized, the need for integrating such information will grow. Consequently, MITOMAP not only provides a valuable reference for the mitochondrial biologist, it may also provide a model for the development of information storage and retrieval systems for other components of the human genome.
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