Nucleic Acids Research, Vol 24, Issue 14 2746-2752, Copyright © 1996 by Oxford University Press
Y Taniguchi, Y Taniguchi-Ueda, K Mori and J Yodoi
Adult T cell leukemia-derived factor (ADF) is a human thioredoxin (Trx) and
is a disulfide reducing protein with various biological functions. We found
that expression of the ADF/Trx gene was increased by oxidative agents such
as hydrogen peroxide, diamide and menadione in Jurkat cells. Analysis using
a CAT expression vector plasmid under the control of the ADF/Trx gene
promoter revealed that CAT gene expression in Jurkat cells was increased
after exposure to oxidative agents. A series of deletion analyses showed
that a region from -976 to -890 of the 5' flanking sequence was required
for enhancement of ADF/Trx promoter activity against the oxidative agents.
Gel mobility shift assay revealed the specific DNA binding activities to
the sequences from -953 to -930 in the nuclear extracts from the Jurkat
cells. The sequences in this region showed no homology with any known
consensus sequences for DNA binding factors. It is suggested that ADF/Trx
gene expression is enhanced through a novel cis-acting regulatory element
responsive for the oxidative stress and a new factor(s) is involved in this
oxidative stress responsive element.
ARTICLES
A novel promoter sequence is involved in the oxidative stress-induced expression of the adult T-cell leukemia-derived factor (ADF)/human thioredoxin (Trx) gene
Department of Anesthesia, Faculty of Medicine, Kyoto University, Japan.
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