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Nucleic Acids Research, Vol 24, Issue 19 3873-3874, Copyright © 1996 by Oxford University Press

ARTICLES

Gene transfer mediated by alpha2-macroglobulin

H Schneider, K Huse, G Birkenmeier, A Otto and GH Scholz
Department of Internal Medicine III, University of Leipzig, Germany.

alpha2-Macroglobulin covalently linked to poly(L)-lysine can be used as a vehicle for receptor-mediated gene transfer. This modified alpha2- macroglobulin maintains its ability to bind to the alpha2-macroglobulin receptor, and was shown to introduce a luciferase reporter gene plasmid into HepG2 human hepatoma cells in vitro. The alpha2-macroglobulin receptor is a very large and multifunctional cell surface receptor, whose rapid and efficient internalization rate makes it attractive for gene therapy, e.g. for hepatic gene targeting via injection into the portal vein.
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