Nucleic Acids Research, Vol 24, Issue 22 4552-4557, Copyright © 1996 by Oxford University Press
K Renner, E Sock, JR Bermingham Jr and M Wegner
Expression of the POU domain protein Tst-1/Oct6 during development of glia
and neurons is subject to a tight multifactorial control. Here we show that
17beta-estradiol increases the level of endogenous Tst-1/Oct6 in glial
cells. This effect was mediated at the level of gene expression by an
enhancer present in the 5' flanking region of the mouse gene for
Tst-1/Oct6, approximately 5 kb upstream of the transcriptional start site.
The enhancer contained as the functional element a sequence motif that
closely resembled a classical estrogen response element. It consisted of an
imperfect palindrome with a spacing of 3 bp, and was bound in vitro by
activated estrogen receptor. Furthermore, this element was able to confer
estrogen responsiveness when introduced into a heterologous promoter. In
the Tst-1/Oct6 gene enhancer, a TPA response element was found in close
proximity to the estrogen receptor binding site. As a consequence, TPA and
estrogen activated transcription of the Tst-1/Oct6 gene in a synergistic
manner.
ARTICLES
Expression of the gene for the POU domain transcription factor Tst- 1/Oct6 is regulated by an estrogen-dependent enhancer
Zentrum fur Molekulare Neurobiologie, Universitat Hamburg, Germany.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. P. Friedrich, B. Schlierf, E. R. Tamm, M. R. Bosl, and M. Wegner The Class III POU Domain Protein Brn-1 Can Fully Replace the Related Oct-6 during Schwann Cell Development and Myelination Mol. Cell. Biol., March 1, 2005; 25(5): 1821 - 1829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ilia, C. Beasley, D. Meijer, R. Kerwin, D. Cotter, I. Everall, and J. Price Expression of Oct-6, a POU III Domain Transcription Factor, in Schizophrenia Am J Psychiatry, July 1, 2002; 159(7): 1174 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Sock, J. Enderich, and M. Wegner The J Domain of Papovaviral Large Tumor Antigen Is Required for Synergistic Interaction with the POU-Domain Protein Tst-1/Oct6/SCIP Mol. Cell. Biol., April 1, 1999; 19(4): 2455 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Driscoll, G. Sathya, M. Muyan, C. M. Klinge, R. Hilf, and R. A. Bambara Sequence Requirements for Estrogen Receptor Binding to Estrogen Response Elements J. Biol. Chem., November 6, 1998; 273(45): 29321 - 29330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schreiber, J. Enderich, E. Sock, C. Schmidt, C. Richter-Landsberg, and M. Wegner Redundancy of Class III POU Proteins in the Oligodendrocyte Lineage J. Biol. Chem., December 19, 1997; 272(51): 32286 - 32293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Sathya, W. Li, C. M. Klinge, J. H. Anolik, R. Hilf, and R. A. Bambara Effects of Multiple Estrogen Responsive Elements, Their Spacing, and Location on Estrogen Response of Reporter Genes Mol. Endocrinol., December 1, 1997; 11(13): 1994 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schreiber, E. Sock, and M. Wegner The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain PNAS, April 29, 1997; 94(9): 4739 - 4744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Baumeister and W. Meyerhof The POU Domain Transcription Factor Tst-1 Activates Somatostatin Receptor 1 Gene Expression in Pancreatic beta -Cells J. Biol. Chem., September 8, 2000; 275(37): 28882 - 28887. [Abstract] [Full Text] [PDF]
|
|