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Nucleic Acids Research, Vol 25, Issue 1 104-106, Copyright © 1997 by Oxford University Press

ARTICLES

The guide RNA database

AE Souza, T Hermann and HU Goringer
Laboratorium fur Molekulare Biologie, Genzentrum der LMU Munchen am MPI fur Biochemie, Am Klopferspitz 18, 82152 Martinsried, Germany.

The RNA editing process in protozoan parasites is controlled by small RNA molecules known as guide RNAs (gRNAs). The gRNA database is a comprehensive compilation of published guide RNA sequences from eight different kinetoplastid organisms. In addition to the RNA primary sequences, information on the gene localization, the experimental verification of the transcripts, and literature citations are provided. Accessory information includes the secondary structures of fourTrypanosoma bruceigRNAs as well as a computer modelled three dimensional gRNA structure. The database is made available as a hypertext document accessible via the World Wide Web (WWW) or from the authors in a printed form.
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