Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (441K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Carter, R. J.
Right arrow Articles by Holbrook, S. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carter, R. J.
Right arrow Articles by Holbrook, S. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, Vol 25, Issue 20 4117-4122, Copyright © 1997 by Oxford University Press

ARTICLES

The crystal structure of an RNA oligomer incorporating tandem adenosine- inosine mismatches

RJ Carter, KJ Baeyens, J SantaLucia, DH Turner and SR Holbrook
Structural Biology Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.

The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
K. Shi, B. Pan, and M. Sundaralingam
The crystal structure of an alternating RNA heptamer r(GUAUACA) forming a six base-paired duplex with 3'-end adenine overhangs
Nucleic Acids Res., March 1, 2003; 31(5): 1392 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
B. Wellenzohn, W. Flader, R. H. Winger, A. Hallbrucker, E. Mayer, and K. R. Liedl
Exocyclic groups in the minor groove influence the backbone conformation of DNA
Nucleic Acids Res., December 15, 2001; 29(24): 5036 - 5043.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. R. Valentine and J. Termini
Kinetics of formation of hypoxanthine containing base pairs by HIV-RT: RNA template effects on the base substitution frequencies
Nucleic Acids Res., March 1, 2001; 29(5): 1191 - 1199.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.