Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (136K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (100)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Yamada, M.
Right arrow Articles by Karran, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamada, M.
Right arrow Articles by Karran, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, Vol 25, Issue 3 491-496, Copyright © 1997 by Oxford University Press

ARTICLES

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins

M Yamada, E O'Regan, R Brown and P Karran
Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

The antitumor agent cis-diamminedichloroplatinum(II) (cisplatin) introduces cytotoxic DNA damage predominantly in the form of intrastrand crosslinks between adjacent purines. Binding assays using a series of duplex oligonucleotides containing a single 1,2 diguanyl intrastrand crosslink indicate that human cell extracts contain factors that preferentially recognise this type of damage when the complementary strand contains T opposite the 3', and C opposite the 5'guanine in the crosslink. Under the conditions of the band-shift assay used, little binding is observed if the positions of the T and C are reversed in the complementary strand. Similarly, duplexes containing CC or TT opposite the crosslink are recognised relatively poorly. The binding activity is absent from extracts of the colorectal carcinoma cell lines LoVo and DLD-1 in which the hMutSalpha mismatch recognition complex is inactivated by mutation. Extensively purified human hMutSalpha exhibits the same substrate preference and binds to the mismatched platinated DNA at least as well as to an identical unplatinated duplex containing a single G.T mismatch. It is likely, therefore, that human mismatch repair may be triggered by 1,2 diguanyl intrastrand crosslinks that have undergone replicative bypass.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
J. A. Brown, S. A. Newmister, K. A. Fiala, and Z. Suo
Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase
Nucleic Acids Res., July 1, 2008; 36(12): 3867 - 3878.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
V. O'Brien and R. Brown
Signalling cell cycle arrest and cell death through the MMR System
Carcinogenesis, April 1, 2006; 27(4): 682 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
X. Lin, J. Trang, T. Okuda, and S. B. Howell
DNA Polymerase {zeta} Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair
Clin. Cancer Res., January 15, 2006; 12(2): 563 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Hamimes, H. Arakawa, A. Z. Stasiak, A. M. Kierzek, S. Hirano, Y.-G. Yang, M. Takata, A. Stasiak, J.-M. Buerstedde, and E. Van Dyck
RDM1, a Novel RNA Recognition Motif (RRM)-containing Protein Involved in the Cell Response to Cisplatin in Vertebrates
J. Biol. Chem., March 11, 2005; 280(10): 9225 - 9235.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
F Bataille, P Rummele, W Dietmaier, D Gaag, F Klebl, A Reichle, P Wild, F Hofstadter, and A Hartmann
Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer
Mol. Pathol., October 1, 2003; 56(5): 286 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. E. Berry, T. Loh, T. Yan, and T. J. Kinsella
Role of MutS{alpha} in the Recognition of Iododeoxyuridine in DNA
Cancer Res., September 1, 2003; 63(17): 5490 - 5495.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Fourrier, P. Brooks, and J.-M. Malinge
Binding Discrimination of MutS to a Set of Lesions and Compound Lesions (Base Damage and Mismatch) Reveals Its Potential Role as a Cisplatin-damaged DNA Sensing Protein
J. Biol. Chem., May 30, 2003; 278(23): 21267 - 21275.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Christmann, M. T. Tomicic, and B. Kaina
Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutS{alpha} mismatch-binding activity
Nucleic Acids Res., May 1, 2002; 30(9): 1959 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Mazurek, M. Berardini, and R. Fishel
Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage
J. Biol. Chem., March 1, 2002; 277(10): 8260 - 8266.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. D. Larson, D. Nickens, and J. T. Drummond
Construction and characterization of mismatch-containing circular DNA molecules competent for assessment of nick-directed human mismatch repair in vitro
Nucleic Acids Res., February 1, 2002; 30(3): e14 - e14.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. Karran
Mechanisms of tolerance to DNA damaging therapeutic drugs
Carcinogenesis, December 1, 2001; 22(12): 1931 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Pepponi, G. Graziani, S. Falcinelli, P. Vernole, L. Levati, P. M. Lacal, E. Pagani, E. Bonmassar, J. Jiricny, and S. D'Atri
hMSH3 overexpression and cellular response to cytotoxic anticancer agents
Carcinogenesis, August 1, 2001; 22(8): 1131 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
V. M. Gonzalez, M. A. Fuertes, C. Alonso, and J. M. Perez
Is Cisplatin-Induced Cell Death Always Produced by Apoptosis?
Mol. Pharmacol., April 1, 2001; 59(4): 657 - 663.
[Full Text]

Home page
 JCOHome page
H. J. Mackay, D. Cameron, M. Rahilly, M. J. Mackean, J. Paul, S. B. Kaye, and R. Brown
Reduced MLH1 Expression in Breast Tumors After Primary Chemotherapy Predicts Disease-Free Survival
J. Clin. Oncol., January 5, 2000; 18(1): 87 - 87.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
G. Aquilina, M. Crescenzi, and M. Bignami
Mismatch repair, G2/M cell cycle arrest and lethality after DNA damage
Carcinogenesis, December 1, 1999; 20(12): 2317 - 2326.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. R. Duckett, S. M. Bronstein, Y. Taya, and P. Modrich
hMutSalpha - and hMutLalpha -dependent phosphorylation of p53 in response to DNA methylator damage
PNAS, October 26, 1999; 96(22): 12384 - 12388.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. A. Johnson, M. L. Mierzwa, S. P. Fink, and L. J. Marnett
MutS Recognition of Exocyclic DNA Adducts That Are Endogenous Products of Lipid Oxidation
J. Biol. Chem., September 17, 1999; 274(38): 27112 - 27118.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
E. D. Scheeff, J. M. Briggs, and S. B. Howell
Molecular Modeling of the Intrastrand Guanine-Guanine DNA Adducts Produced by Cisplatin and Oxaliplatin
Mol. Pharmacol., September 1, 1999; 56(3): 633 - 643.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
H. Terato, A. Masaoka, M. Kobayashi, S. Fukushima, Y. Ohyama, M. Yoshida, and H. Ide
Enzymatic Repair of 5-Formyluracil. II. MISMATCH FORMATION BETWEEN 5-FORMYLURACIL AND GUANINE DURING DNA REPLICATION AND ITS RECOGNITION BY TWO PROTEINS INVOLVED IN BASE EXCISION REPAIR (AlkA) AND MISMATCH REPAIR (MutS)
J. Biol. Chem., August 27, 1999; 274(35): 25144 - 25150.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
X. Lin and S. B. Howell
Effect of Loss of DNA Mismatch Repair on Development of Topotecan-, Gemcitabine-, and Paclitaxel-Resistant Variants after Exposure to Cisplatin
Mol. Pharmacol., August 1, 1999; 56(2): 390 - 395.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
M. Wakasugi and A. Sancar
Order of Assembly of Human DNA Repair Excision Nuclease
J. Biol. Chem., June 25, 1999; 274(26): 18759 - 18768.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. O'Driscoll, S. Martinelli, C. Ciotta, and P. Karran
Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage
Carcinogenesis, May 1, 1999; 20(5): 799 - 804.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. J. Toft, D. J. Winton, J. Kelly, L. A. Howard, M. Dekker, H. te Riele, M. J. Arends, A. H. Wyllie, G. P. Margison, and A. R. Clarke
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine
PNAS, March 30, 1999; 96(7): 3911 - 3915.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Bertrand, D. X. Tishkoff, N. Filosi, R. Dasgupta, and R. D. Kolodner
Physical interaction between components of DNA mismatch repair and nucleotide excision repair
PNAS, November 24, 1998; 95(24): 14278 - 14283.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Modrich
Strand-specific Mismatch Repair in Mammalian Cells
J. Biol. Chem., October 3, 1997; 272(40): 24727 - 24730.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. D. Wood
Nucleotide Excision Repair in Mammalian Cells
J. Biol. Chem., September 19, 1997; 272(38): 23465 - 23468.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Berardini, A. Mazurek, and R. Fishel
The Effect of O6-Methylguanine DNA Adducts on the Adenosine Nucleotide Switch Functions of hMSH2-hMSH6 and hMSH2-hMSH3
J. Biol. Chem., September 1, 2000; 275(36): 27851 - 27857.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Christmann and B. Kaina
Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents
J. Biol. Chem., November 10, 2000; 275(46): 36256 - 36262.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. D. Larson and J. T. Drummond
Human Mismatch Repair and G{middle dot}T Mismatch Binding by hMutSalpha in Vitro Is Inhibited by Adriamycin, Actinomycin D, and Nogalamycin
J. Biol. Chem., March 23, 2001; 276(13): 9775 - 9783.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.