Nucleic Acids Research, Vol 25, Issue 4 794-799, Copyright © 1997 by Oxford University Press
JR Ryu, TY Choi, EJ Kwon, WH Lee, Y Nishida, Y Hayashi, A Matsukage, M Yamaguchi and MA Yoo
The DRE/DREF system plays an important role in transcription of DNA
replication genes such as those encoding the 180 and 73 kDa subunits of DNA
polymerase alpha as well as that for encoding PCNA. In this study, we found
two sequences homologous to DRE (5'-TATCGATA-3') in the 5'- flanking region
(-370 to -357 with respect to the transcription initiation site) of the
D-raf gene and confirmed transcriptional activity through gel mobility
shift assays, transient CAT assays, and spatial patterns of lacZ expression
in transgenic larval tissues carrying D-raf and lacZ fusion genes. Further,
we demonstrated that the D-raf gene is another target of the Zerknullt
(Zen) protein with observation of D-raf repression by Zen protein in
cultured cells and its ectopic expression in the dorsal region of the
homozygous zen mutant embryo. The evidence of DRE/DREF involvement in
regulation of the D-raf gene obtained in this study strongly supports the
idea that the DRE/DREF system is responsible for the coordinated regulation
of cell proliferation-related genes in Drosophila.
ARTICLES
Transcriptional regulation of the Drosophila-raf proto-oncogene by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system
Department of Molecular Biology, College of Natural Science, Pusan National University, Korea.
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