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Nucleic Acids Research, Vol 26, Issue 1 226-228, Copyright © 1998 by Oxford University Press

ARTICLES

aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server

X Cousin, T Hotelier, K Giles, JP Toutant and A Chatonnet
Differenciation Cellulaire et Croissance and Unite Informatique, INRA- ENSAM, 2 place Viala, 34060 Montpellier, France.

Acetylcholinesterase belongs to a family of proteins, the alpha/beta hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor and share a similar structure of a central beta sheet surrounded by alpha helices. These proteins fulfil a wide range of physiological functions (hydrolases, adhesion molecules, hormone precursors) [Krejci,E., Duval,N., Chatonnet,A., Vincens,P. and Massoulie,J. (1991) Proc. Natl. Acad. Sci. USA , 88, 6647-6651]. ESTHER (for esterases, alpha/beta hydrolase enzymes and relatives) is a database aimed at collecting in one information system, sequence data together with biological annotations and experimental biochemical results related to the structure-function analysis of the enzymes of the family. The major upgrade of the database comes from the use of a new database management system: aCHEdb which uses the ACeDB program designed by Richard Durbin and Jean Thierry-Mieg. It can be found at http://www.ensam.inra.fr/cholinesterase
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