Nucleic Acids Research, Vol 26, Issue 1 234-238, Copyright © 1998 by Oxford University Press
B Gottlieb, H Lehvaslaiho, LK Beitel, R Lumbroso, L Pinsky and M Trifiro
The current version of the androgen receptor (AR) gene mutations database
is described. The total number of reported mutations has risen from 272 to
309 in the past year. We have expanded the database: (i) by giving each
entry an accession number; (ii) by adding information on the length of
polymorphic polyglutamine (polyGln) and polyglycine (polyGly) tracts in
exon 1; (iii) by adding information on large gene deletions; (iv) by
providing a direct link with a completely searchable database (courtesy
EMBL-European Bioinformatics Institute). The addition of the exon 1
polymorphisms is discussed in light of their possible relevance as markers
for predisposition to prostate or breast cancer. The database is also
available on the internet (http://www.mcgill. ca/androgendb/ ), from
EMBL-European Bioinformatics Institute (ftp.
ebi.ac.uk/pub/databases/androgen ), or as a Macintosh FilemakerPro or Word
file (MC33@musica.mcgill.ca).
ARTICLES
The Androgen Receptor Gene Mutations Database
Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Chemin de la Cote-Ste- Catherine, Montreal, Quebec H3T 1E2, Canada. mc33@musica.mcgill.ca
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