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Nucleic Acids Research, Vol 26, Issue 1 275-279, Copyright © 1998 by Oxford University Press

ARTICLES

GPCRDB: an information system for G protein-coupled receptors

F Horn, J Weare, MW Beukers, S Horsch, A Bairoch, W Chen, O Edvardsen, F Campagne and G Vriend
BIOcomputing, EMBL, Heidelberg, Germany.

The GPCRDB is a G protein-coupled receptor (GPCR) database system aimed at the collection and dissemination of GPCR related data. It holds sequences, mutant data and ligand binding constants as primary (experimental) data. Computationally derived data such as multiple sequence alignments, three dimensional models, phylogenetic trees and two dimensional visualization tools are added to enhance the database's usefulness. The GPCRDB is an EU sponsored project aimed at building a generic molecular class specific database capable of dealing with highly heterogeneous data. GPCRs were chosen as test molecules because of their enormous importance for medical sciences and due to the availability of so much highly heterogeneous data. The GPCRDB is available via the WWW at http://www.gpcr.org/7tm
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[Abstract] [Full Text] [PDF]

Home page
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T. Mirzadegan, F. Diehl, B. Ebi, S. Bhakta, I. Polsky, D. McCarley, M. Mulkins, G. S. Weatherhead, J.-M. Lapierre, J. Dankwardt, et al.
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J. Biol. Chem., August 11, 2000; 275(33): 25562 - 25571.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., June 16, 2000; 275(25): 19000 - 19008.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., April 13, 2001; 276(16): 13217 - 13225.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., June 15, 2001; 276(25): 22991 - 22999.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., September 21, 2001; 276(39): 36652 - 36663.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., October 5, 2001; 276(41): 37944 - 37949.
[Abstract] [Full Text] [PDF]

Home page
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