Nucleic Acids Research, Vol 26, Issue 1 297-303, Copyright © 1998 by Oxford University Press
MP Lefranc, V Giudicelli, C Busin, J Bodmer, W Muller, R Bontrop, M Lemaitre, A Malik and D Chaume
IMGT, the international ImMunoGeneTics database, is an integrated database
specialising in Immunoglobulins (Ig), T cell Receptors (TcR) and Major
Histocompatibility Complex (MHC) of all vertebrate species, created by
Marie-Paule Lefranc, CNRS, Montpellier II University, Montpellier, France
(lefranc@ligm.crbm.cnrs-mop.fr). IMGT includes three databases: LIGM-DB
(for Ig and TcR), MHC/HLA-DB and PRIMER-DB (the last two in development).
IMGT comprises expertly annotated sequences and alignment tables. LIGM-DB
contains more than 23 000 Immunoglobulin and T cell Receptor sequences from
78 species. MHC/HLA- DB contains Class I and Class II Human Leucocyte
Antigen alignment tables. An IMGT tool, DNAPLOT, developed for Ig, TcR and
MHC sequence alignments, is also available. IMGT works in close
collaboration with the EMBL database. IMGT goals are to establish a common
data access to all immunogenetics data, including nucleotide and protein
sequences, oligonucleotide primers, gene maps and other genetic data of Ig,
TcR and MHC molecules, and to provide a graphical user friendly data
access. IMGT has important implications in medical research (repertoire in
autoimmune diseases, AIDS, leukemias, lymphomas), therapeutical approaches
(antibody engineering), genome diversity and genome evolution studies. IMGT
is freely available at http://imgt.cnusc.fr:8104
ARTICLES
IMGT, the International ImMunoGeneTics database
Laboratoire d'ImmunoGenetique Moleculaire, LIGM, UMR 5535 (CNRS, Universite Montpellier II), 1919 route de Mende, 34293 Montpellier Cedex 5, France. lefranc.ligm.crbm.cnrs-mop.fr
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