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Nucleic Acids Research, Vol 26, Issue 13 3173-3178, Copyright © 1998 by Oxford University Press

ARTICLES

Caged RNA: photo-control of a ribozyme reaction

SG Chaulk and AM MacMillan
Department of Chemistry, University of Toronto, Toronto, Ontario M5S- 3HC, Canada.

We report here the first photo-chemical control of a ribozyme reaction by the site-specific modification of the 2'-hydroxyl nucleophile in the hammerhead system with a caging functionality. Rapid laser photolysis of the O-(2-nitrobenzyl) caging group initiates an efficient and accurate hammerhead-catalyzed cleavage of substrate RNA under native conditions. RNAs in which reactive functionalities or recognition elements are caged in this manner will be useful tools to probe RNA reactivity and dynamics.
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