Nucleic Acids Research, Vol 26, Issue 17 4056-4062, Copyright © 1998 by Oxford University Press
KJ Dechering, K Cuelenaere, RN Konings and JA Leunissen
The unusual base composition of the genome of the human malaria parasite
Plasmodium falciparum prompted us to systematically investigate the
occurrence of homopolymeric DNA tracts in the P. falciparum genome and, for
comparison, in the genomes of Homo sapiens , Saccharomyces cerevisiae ,
Caenorhabditis elegans , Arabidopsis thaliana , Escherichia coli and
Mycobacterium tuberculosis. Comparison of theobserved frequencies with the
frequencies as expected for random DNA revealed that homopolymeric (dA:dT)
tracts occur well above chance in the eukaryotic genome. In the majority of
these genomes, (dA:dT) tract overrepresentation proved to be an exponential
function of the tract length. (dG:dC) tract overrepresentation was absent
or less pronounced in both prokaryotic and eukaryotic genomes. On the basis
of our results, we propose that homopolymeric (dA:dT) tracts are expanded
via replication slippage. This slippage-mediated expansion does not operate
on tracts with lengths below a critical threshold of 7-10 bp.
ARTICLES
Distinct frequency-distributions of homopolymeric DNA tracts in different genomes
Department of Molecular Biology and CAOS/CAMM Center, University of Nijmegen, Toernooiveld 1,6525 ED Nijmegen, The Netherlands.
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