Nucleic Acids Research, Vol 26, Issue 18 4121-4128, Copyright © 1998 by Oxford University Press
R Hartmann, HS Olsen, S Widder, R Jorgensen and J Justesen
The 2'-5' oligoadenylate synthetases form a well conserved family of
interferon induced proteins, presumably present throughout the mammalian
class. Using the Expressed Sequence Tag databases, we have identified a
novel member of this family. This protein, which we named p59 2'-5'
oligoadenylate synthetase-like protein (p59OASL), shares a highly conserved
N-terminal domain with the known forms of 2'-5' oligoadenylate synthetases,
but differs completely in its C-terminal part. The C-terminus of p59OASL is
formed of two domains of ubiquitin- like sequences. Here we present the
characterisation of a full-length cDNA clone, the genomic sequence and the
expression pattern of this gene. We have addressed the evolution of the
2'-5' oligoadenylate synthetase gene family, in the light of both this new
member and new 2'- 5' oligoadenylate synthetase sequence data from other
species, which have recently appeared in the databases.
ARTICLES
p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family
Department of Molecular and Structural Biology, University of Aarhus, C. F. Mollers alle Building 130, DK-8000 Aarhus C, Denmark and Human Genome Sciences Inc., 9410 Key West Avenue, Rockville, MD 20850, USA.
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