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Nucleic Acids Research, Vol 27, Issue 1 260-262, Copyright © 1999 by Oxford University Press


ARTICLES

Pfam 3.1: 1313 multiple alignments and profile HMMs match the majority of proteins

A Bateman, E Birney, R Durbin, SR Eddy, RD Finn and EL Sonnhammer
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. agb@sanger.ac.uk

Pfam is a collection of multiple alignments and profile hidden Markov models of protein domain families. Release 3.1 is a major update of the Pfam database and contains 1313 families which are available on the World Wide Web in Europe at http://www.sanger.ac.uk/Software/Pfam/ and http://www.cgr.ki.se/Pfam/, and in the US at http://pfam.wustl.edu/. Over 54% of proteins in SWISS-PROT-35 and SP-TrEMBL-5 match a Pfam family. The primary changes of Pfam since release 2.1 are that we now use the more advanced version 2 of the HMMER software, which is more sensitive and provides expectation values for matches, and that it now includes proteins from both SP-TrEMBL and SWISS-PROT.
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Genome ResHome page
M. Hirosawa, K.-i. Ishikawa, T. Nagase, and O. Ohara
Detection of Spurious Interruptions of Protein-Coding Regions in Cloned cDNA Sequences by GeneMark Analysis
Genome Res., September 1, 2000; 10(9): 1333 - 1341.
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J. Bacteriol.Home page
W. Brabetz, C. E. Schirmer, and H. Brade
3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Transferase of Legionella pneumophila Transfers Two Kdo Residues to a Structurally Different Lipid A Precursor of Escherichia coli
J. Bacteriol., August 15, 2000; 182(16): 4654 - 4657.
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NeurologyHome page
B. A. Minassian, L. Ianzano, M. Meloche, E. Andermann, G. A. Rouleau, A. V. Delgado-Escueta, and S. W. Scherer
Mutation spectrum and predicted function of laforin in Lafora's progressive myoclonus epilepsy
Neurology, August 8, 2000; 55(3): 341 - 346.
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Nucleic Acids ResHome page
X. Shao and N. V. Grishin
Common fold in helix-hairpin-helix proteins
Nucleic Acids Res., July 15, 2000; 28(14): 2643 - 2650.
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Genome ResHome page
N. V. Grishin, Y. I. Wolf, and E. V. Koonin
From Complete Genomes to Measures of Substitution Rate Variability Within and Between Proteins
Genome Res., July 1, 2000; 10(7): 991 - 1000.
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N. Mitsuhashi, T. Miki, H. Senbongi, N. Yokoi, H. Yano, M. Miyazaki, N. Nakajima, T. Iwanaga, Y. Yokoyama, T. Shibata, et al.
MTABC3, a Novel Mitochondrial ATP-binding Cassette Protein Involved in Iron Homeostasis
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Genome ResHome page
A.-M. Mallon, M. Platzer, R. Bate, G. Gloeckner, M.R.M. Botcherby, G. Nordsiek, M.A. Strivens, P. Kioschis, A. Dangel, D. Cunningham, et al.
Comparative Genome Sequence Analysis of the Bpa/Str Region in Mouse and Man
Genome Res., June 1, 2000; 10(6): 758 - 775.
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Protein Eng Des SelHome page
C.J. J. Francoijs, J. P.G. Klomp, and R. M.A. Knegtel
Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling
Protein Eng. Des. Sel., June 1, 2000; 13(6): 391 - 394.
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J. G. Henikoff and S. Henikoff
Drosophila Genomic Sequence Annotation Using the BLOCKS+ Database
Genome Res., April 1, 2000; 10(4): 543 - 546.
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M. T. Bedford, D. Sarbassova, J. Xu, P. Leder, and M. B. Yaffe
A Novel Pro-Arg Motif Recognized by WW Domains
J. Biol. Chem., March 31, 2000; 275(14): 10359 - 10369.
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ScienceHome page
G. M. Rubin, M. D. Yandell, J. R. Wortman, G. L. Gabor Miklos, C. R. Nelson, I. K. Hariharan, M. E. Fortini, P. W. Li, R. Apweiler, W. Fleischmann, et al.
Comparative Genomics of the Eukaryotes
Science, March 24, 2000; 287(5461): 2204 - 2215.
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Protein Eng Des SelHome page
J.E. Bray, A.E. Todd, F.M.G. Pearl, J.M. Thornton, and C.A. Orengo
The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues
Protein Eng. Des. Sel., March 1, 2000; 13(3): 153 - 165.
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J. Bacteriol.Home page
S. Güler, B. Essigmann, and C. Benning
A Cyanobacterial Gene, sqdX, Required for Biosynthesis of the Sulfolipid Sulfoquinovosyldiacylglycerol
J. Bacteriol., January 15, 2000; 182(2): 543 - 545.
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Nucleic Acids ResHome page
G. Yona, N. Linial, and M. Linial
ProtoMap: automatic classification of protein sequences and hierarchy of protein families
Nucleic Acids Res., January 1, 2000; 28(1): 49 - 55.
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Nucleic Acids ResHome page
N. J. Schisler and J. D. Palmer
The IDB and IEDB: intron sequence and evolution databases
Nucleic Acids Res., January 1, 2000; 28(1): 181 - 184.
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T. K. Attwood, M. D. R. Croning, D. R. Flower, A. P. Lewis, J. E. Mabey, P. Scordis, J. N. Selley, and W. Wright
PRINTS-S: the database formerly known as PRINTS
Nucleic Acids Res., January 1, 2000; 28(1): 225 - 227.
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Nucleic Acids ResHome page
J. G. Henikoff, E. A. Greene, S. Pietrokovski, and S. Henikoff
Increased coverage of protein families with the Blocks Database servers
Nucleic Acids Res., January 1, 2000; 28(1): 228 - 230.
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Nucleic Acids ResHome page
J. Murvai, K. Vlahovicek, E. Barta, B. Cataletto, and S. Pongor
The SBASE protein domain library, release 7.0: a collection of annotated protein sequence segments
Nucleic Acids Res., January 1, 2000; 28(1): 260 - 262.
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A. Bateman, E. Birney, R. Durbin, S. R. Eddy, K. L. Howe, and E. L. L. Sonnhammer
The Pfam Protein Families Database
Nucleic Acids Res., January 1, 2000; 28(1): 263 - 266.
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Nucleic Acids ResHome page
F. Corpet, F. Servant, J. Gouzy, and D. Kahn
ProDom and ProDom-CG: tools for protein domain analysis and whole genome comparisons
Nucleic Acids Res., January 1, 2000; 28(1): 267 - 269.
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A. Krause, J. Stoye, and M. Vingron
The SYSTERS protein sequence cluster set
Nucleic Acids Res., January 1, 2000; 28(1): 270 - 272.
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Nucleic Acids ResHome page
H. Huang, C. Xiao, and C. H. Wu
ProClass protein family database
Nucleic Acids Res., January 1, 2000; 28(1): 273 - 276.
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R. Kikuno, T. Nagase, M. Suyama, M. Waki, M. Hirosawa, and O. Ohara
HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project
Nucleic Acids Res., January 1, 2000; 28(1): 331 - 332.
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Nucleic Acids ResHome page
M. D'Souza, M. F. Romine, and N. Maltsev
SENTRA, a database of signal transduction proteins
Nucleic Acids Res., January 1, 2000; 28(1): 335 - 336.
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GeneticsHome page
M. Ashburner, S. Misra, J. Roote, S. E. Lewis, R. Blazej, T. Davis, C. Doyle, R. Galle, R. George, N. Harris, et al.
An Exploration of the Sequence of a 2.9-Mb Region of the Genome of Drosophila melanogaster: The Adh Region
Genetics, September 1, 1999; 153(1): 179 - 219.
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GeneticsHome page
P. D. Rabinowicz, E. L. Braun, A. D. Wolfe, B. Bowen, and E. Grotewold
Maize R2R3 Myb Genes: Sequence Analysis Reveals Amplification in the Higher Plants
Genetics, September 1, 1999; 153(1): 427 - 444.
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H Stenmark and R Aasland
FYVE-finger proteins--effectors of an inositol lipid
J. Cell Sci., January 12, 1999; 112(23): 4175 - 4183.
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S. Zimmer, A. Stocker, M. N. Sarbolouki, S. E. Spycher, J. Sassoon, and A. Azzi
A Novel Human Tocopherol-associated Protein. CLONING, IN VITRO EXPRESSION, AND CHARACTERIZATION
J. Biol. Chem., August 11, 2000; 275(33): 25672 - 25680.
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B. C. Low, K. T. Seow, and G. R. Guy
The BNIP-2 and Cdc42GAP Homology Domain of BNIP-2 Mediates Its Homophilic Association and Heterophilic Interaction with Cdc42GAP
J. Biol. Chem., November 22, 2000; 275(48): 37742 - 37751.
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G. Faulkner, A. Pallavicini, A. Comelli, M. Salamon, G. Bortoletto, C. Ievolella, S. Trevisan, S. Kojic', F. Dalla Vecchia, P. Laveder, et al.
FATZ, a Filamin-, Actinin-, and Telethonin-binding Protein of the Z-disc of Skeletal Muscle
J. Biol. Chem., December 22, 2000; 275(52): 41234 - 41242.
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V. Gervais, D. Busso, E. Wasielewski, A. Poterszman, J.-M. Egly, J.-C. Thierry, and B. Kieffer
Solution Structure of the N-terminal Domain of the Human TFIIH MAT1 Subunit. NEW INSIGHTS INTO THE RING FINGER FAMILY
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