Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (203K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Bachmeyer, C.
Right arrow Articles by Wu, L. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bachmeyer, C.
Right arrow Articles by Wu, L. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, Vol 27, Issue 2 643-648, Copyright © 1999 by Oxford University Press

ARTICLES

Regulation by phosphorylation of the zinc finger protein KRC that binds the kappaB motif and V(D)J recombination signal sequences

C Bachmeyer, CH Mak, CY Yu and LC Wu
Department of Internal Medicine and Department of Medical Biochemistry, Ohio State University, Columbus, OH 43210, USA.

The DNA binding protein KRC (forkappaB binding andrecognitioncomponent of the V(D)J recombination signal sequence) belongs to a family of large zinc finger proteins that bind to the kappaB motif and contains two widely separated DNA binding structures. In addition to the kappaB motif, KRC fusion proteins bind to the signal sequences of V(D)J recombination to form highly ordered complexes. Here, we report that KRC may be regulated by post-translational modifications. Specific protein kinases present in the nucleus of pre-B cells phosphorylated a KRC fusion protein at tyrosine and serine residues. Such protein modifications increased DNA binding, thereby providing a mechanism by which KRC responds to signal transduction pathways. KRC is a substrate of epidermal growth factor receptor kinase and P34cdc2 kinase in vitro. Our results suggest that activation of the KRC family of transcription factors may provide a mechanism by which oncogenic tyrosine kinases regulate genes with kappaB-controlled gene regulatory elements.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JEMHome page
M. Y. Kimura, H. Hosokawa, M. Yamashita, A. Hasegawa, C. Iwamura, H. Watarai, M. Taniguchi, T. Takagi, S. Ishii, and T. Nakayama
Regulation of T helper type 2 cell differentiation by murine Schnurri-2
J. Exp. Med., February 7, 2005; 201(3): 397 - 408.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Oukka, M. N. Wein, and L. H. Glimcher
Schnurri-3 (KRC) Interacts with c-Jun to Regulate the IL-2 Gene in T Cells
J. Exp. Med., January 5, 2004; 199(1): 15 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Takeda, M. Arima, N. Tsuruoka, S. Okada, M. Hatano, A. Sakamoto, Y. Kohno, and T. Tokuhisa
Bcl6 Is a Transcriptional Repressor for the IL-18 Gene
J. Immunol., July 1, 2003; 171(1): 426 - 431.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Arima, H. Toyama, H. Ichii, S. Kojima, S. Okada, M. Hatano, G. Cheng, M. Kubo, T. Fukuda, and T. Tokuhisa
A Putative Silencer Element in the IL-5 Gene Recognized by Bcl6
J. Immunol., July 15, 2002; 169(2): 829 - 836.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Hjelmsoe, C. E. Allen, M. A. Cohn, E. M. Tulchinsky, and L.-C. Wu
The kappa B and V(D)J Recombination Signal Sequence Binding Protein KRC Regulates Transcription of the Mouse Metastasis-associated Gene S100A4/mts1
J. Biol. Chem., January 14, 2000; 275(2): 913 - 920.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.