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Nucleic Acids Research, Vol 27, Issue 4 949-955, Copyright © 1999 by Oxford University Press

ARTICLES

A'-form RNA double helix in the single crystal structure of r(UGAGCUUCGGCUC)

Y Tanaka, S Fujii, H Hiroaki, T Sakata, T Tanaka, S Uesugi, K Tomita and Y Kyogoku
Division of Molecular Biophysics, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565, Japan. tanaka@protein.osaka-u.ac.jp

Here we demonstrate the presence of the A'-RNA conformation using the single crystal structure of a tridecamer: r(UGAGCUUCGGCUC). The average A'-RNA conformation deduced from X-ray fiber diffraction data had only been available previously, but now the presence of the A'-RNA conformation has been found in a single crystal structure for the first time. Statistical analysis showed that the A'-RNA conformation is distinguishable from the A-RNA conformation in a plot of the major groove width against the base pair inclination angle. The major groove of the A'-RNA conformation is wide enough to accommodate a protein or peptide while that of the A-RNA conformation is too narrow to do so. The presence of the A'-RNA conformation is significant for protein-RNA interaction.
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