Nucleic Acids Research, 2000, Vol. 28, No. 1 193-196
© 2000 Oxford University Press
UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs
1Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, 20133 Milano, Italy, 2Area di Ricerca di Bari, Consiglio Nazionale delle Ricerche (CNR), via Amendola 166/5, 70126 Bari, Italy, 3Centro di Studio sui Mitocondri e Metabolismo Energetico del Consiglio Nazionale delle Ricerche (CNR), via Orabona 4, 70126 Bari, Italy, 4Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, via Orabona 4, 70126 Bari, Italy and 5National Center for Biotechnology Information, NLM-NIH, Bethesda, MD, USA
The 5' and 3' untranslated regions of eukaryotic mRNAs may play a crucial role in the regulation of gene expression controlling mRNA localization, stability and translational efficiency. For this reason we developed UTRdb, a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements. All internet resources implemented for retrieval and functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs are accessible at http://bigarea.area.ba.cnr.it:8000/EmbIT/UTRHome/
* To whom correspondence should be addressed at: Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, 20133 Milano, Italy. Tel: +39 02 7064 4803; Fax: +39 02 7063 2811; Email: graziano.pesole@unimi.it
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