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Nucleic Acids Research, 2000, Vol. 28, No. 1 225-227
© 2000 Oxford University Press

PRINTS-S: the database formerly known as PRINTS

T. K. Attwood1,*, M. D. R. Croning1,2, D. R. Flower3, A. P. Lewis4, J. E. Mabey1, P. Scordis1, J. N. Selley1 and W. Wright1

1School of Biological Sciences, The University of Manchester, Manchester M13 9PT, UK, 2European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 3The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK and 4Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

The PRINTS database houses a collection of protein family fingerprints. These are groups of motifs that together are diagnostically more potent than single motifs by virtue of the biological context afforded by matching motif neighbours. Around 1200 fingerprints have now been created and stored in the database. The September 1999 release (version 24.0) encodes ~7200 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here several major changes to the resource, including the design of an automated strategy for database maintenance, and implementation of an object-relational schema for more efficient data management. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/

* To whom correspondence should be addressed. Tel: +44 161 275 5766; Fax: +44 161 275 5082; Email: attwood@bioinf.man.ac.uk


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