Nucleic Acids Research, 2000, Vol. 28, No. 1 231-234
© 2000 Oxford University Press
SMART: a web-based tool for the study of genetically mobile domains
1EMBL, Meyerhofstrasse1, 69012 Heidelberg, Germany, 2Max-Delbrück-Center, Berlin-Buch, Germany and 3MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.
* To whom correspondence should be addressed at: EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany. Tel: +49 6221 387526; Fax: +49 6221 387517; Email: bork@embl-heidelberg.de
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