Nucleic Acids Research, 2000, Vol. 28, No. 1 316-319
© 2000 Oxford University Press
TRANSFAC: an integrated system for gene expression regulation
1Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany, 2The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, People’s Republic of China, 3Technische Universität Braunschweig, Biozentrum, D-39100 Braunschweig, Germany and 4BIOBASE GmbH, Mascheroder Weg 1B, D-38124 Braunschweig, Germany
TRANSFAC is a database on transcription factors, their genomic binding sites and DNA-binding profiles (http://transfac.gbf.de/TRANSFAC/ ). Its content has been enhanced, in particular by information about training sequences used for the construction of nucleotide matrices as well as by data on plant sites and factors. Moreover, TRANSFAC has been extended by two new modules: PathoDB provides data on pathologically relevant mutations in regulatory regions and transcription factor genes, whereas S/MARt DB compiles features of scaffold/matrix attached regions (S/MARs) and the proteins binding to them. Additionally, the databases TRANSPATH, about signal transduction, and CYTOMER, about organs and cell types, have been extended and are increasingly integrated with the TRANSFAC data sources.
* To whom correspondence should be addressed. Tel: +49 531 6181 427; Fax: +49 531 6181 266; Email: ewi@gbf.de
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