Nucleic Acids Research, 2000, Vol. 28, No. 1 320-322
© 2000 Oxford University Press
The Histone Database: a comprehensive WWW resource for histones and histone fold-containing proteins
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A Room 8N805, Bethesda, MD 20894, USA, 1Department of Biology, Texas A&M University, College Station, TX 70843, USA and 2Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-4470, USA
The Histone Database (HDB) is an annotated and searchable collection of all full-length sequences and structures of histone and non-histone proteins containing the histone fold motif. These sequences are both eukaryotic and archaeal in origin. Several new histone fold-containing proteins have been identified, including Spt7p, and a few false positives have been removed from the earlier version of HDB. Database contents include compilations of post-translational modifications for each of the core and linker histones, as well as genomic information in the form of map loci for the human histone gene complement, with the genetic loci linked to Online Mendelian Inheritance in Man (OMIM). Conflicts between similar sequence entries from a number of source databases are also documented. Newly added to the HDB are multiple sequence alignments in which predicted functions of histone fold amino acid residues are annotated. The database is freely accessible through the WWW at http://genome.nhgri.nih.gov/histones/
* To whom correspondence should be addressed. Tel: +1 301 435 5981; Fax: +1 301 480 9241; Email: landsman@ncbi.nlm.nih.gov
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