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Nucleic Acids Research, 2000, Vol. 28, No. 1 341-343
© 2000 Oxford University Press

Olfactory Receptor Database: a sensory chemoreceptor resource

Emmanouil Skoufos1,2,*, Luis Marenco1, Prakash M. Nadkarni1, Perry L. Miller1 and Gordon M. Shepherd2

1Center for Medical Informatics and 2Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06511, USA

The Olfactory Receptor Database (ORDB) is a WWW-accessible database that has been expanded from an olfactory receptor resource to a chemoreceptor resource. It stores data on six classes of G-protein-coupled sensory chemoreceptors: (i) olfactory receptor-like proteins, (ii) vomeronasal receptors, (iii) insect olfactory receptors, (iv) worm chemo­receptors, (v) taste papilla receptors and (vi) fungal pheromone receptors. A complementary database of the ligands of these receptors (OdorDB) has been constructed and is publicly available in a pilot mode. The database schema of ORDB has been changed from traditional relational to EAV/CR (Entity-Attribute-Value with Classes and Relationships), which allows the interoperability of ORDB with other related databases as well as the creation of intra­database associations among objects. This inter­operability facilitates users to follow information from odor molecule binding to its putative receptor, to the properties of the neuron expressing the receptor, to a computational model of activity of olfactory bulb neurons. In addition, tools and resources have been added allowing users to access interactive phylogenetic trees and alignments of sensory chemoreceptors. ORDB is available via the WWW at http://ycmi.med.yale.edu/senselab/ordb/

* To whom correspondence should be addressed. Tel: +1 203 785 3730; Fax: +1 203 785 6990; Email: emmanouil.skoufos@yale.edu Present address: Emmanouil Skoufos, 3rd Millennium Inc., 125 Cambridge Park Drive, Cambridge, MA 02140, USA


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