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Nucleic Acids Research, 2000, Vol. 28, No. 1 361-363
© 2000 Oxford University Press

ALFRED: an allele frequency database for diverse populations and DNA polymorphisms

Kei-Hoi Cheung, Michael V. Osier1, Judith R. Kidd1, Andrew J. Pakstis1, Perry L. Miller and Kenneth K. Kidd1,*

Center for Medical Informatics, Yale University School of Medicine, 333 Cedar Street, PO Box 208009, New Haven, CT 06520-8009, USA and 1Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT 06520-8005, USA

We have developed a publicly accessible database (ALFRED, the ALlele FREquency Database) that catalogues allele frequency data for a wide range of population samples and DNA polymorphisms. This database is web-accessible through our laboratory (Kidd Lab) Web site: http://info.med.yale.edu/genetics/kkidd . ALFRED currently contains data on 60 populations and 156 genetic systems including single nucleotide polymorphisms (SNPs), short tandem repeat polymorphisms (STRPs), variable number of tandem repeats (VNTRs) and insertion–deletion polymorphisms. While data are not available for all population–DNA polymorphism combinations, over 2000 allele frequency tables have been entered. Our database is designed (i) to address our specific research requirements as well as broader scientific objectives; (ii) to allow researchers and interested educators to easily navigate and retrieve data of interest to them; and (iii) to integrate links to other related public databases such as dbSNP, GenBank and PubMed.

* To whom correspondence should be addressed: Tel: +1 203 785 2654; Fax: +1 203 785 6568; Email: kidd@biomed.med.yale.edu The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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