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Nucleic Acids Research, 2000, Vol. 28, No. 1 87-90
© 2000 Oxford University Press

The Phytophthora Genome Initiative Database: informatics and analysis for distributed pathogenomic research

Mark Waugh, Peter Hraber, Jennifer Weller, Yihe Wu, Guonghong Chen, Jeff Inman, Don Kiphart and Bruno Sobral*

The National Center for Genome Resources, 1800A Old Pecos Trail, Santa Fe, NM 87505, USA

The Phytophthora Genome Initiative (PGI) is a distributed collaboration to study the genome and evolution of a particularly destructive group of plant pathogenic oomycete, with the goal of understanding the mechanisms of infection and resistance. NCGR provides informatics support for the collaboration as well as a centralized data repository. In the pilot phase of the project, several investigators prepared Phytophthora infestans and Phytophthora sojae EST and Phytophthora sojae BAC libraries and sent them to another laboratory for sequencing. Data from sequencing reactions were transferred to NCGR for analysis and curation. An analysis pipeline transforms raw data by performing simple analyses (i.e., vector removal and similarity searching) that are stored and can be retrieved by investigators using a web browser. Here we describe the database and access tools, provide an overview of the data therein and outline future plans. This resource has provided a unique opportunity for the distributed, collaborative study of a genus from which relatively little sequence data are available. Results may lead to insight into how better to control these pathogens. The homepage of PGI can be accessed at http:www.ncgr.org/pgi , with database access through the database access hyperlink.

* To whom correspondence should be addressed. Tel: +1 505 995 4473; Fax: +1 505 995 4432; Email: bws@ncgr.org


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