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Nucleic Acids Research, 2000, Vol. 28, No. 18 3442-3444
© 2000 Oxford University Press

STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene

B. Snel1,*, G. Lehmann2, P. Bork1,2 and M. A. Huynen1,2

1European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany and 2Max-Delbruck-Centrum for Molecular Medicine, D-13122 Berlin-Buch, Germany

The repeated occurrence of genes in each other’s neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity. STRING is available at http://www.bork.embl-heidelberg.de/STRING

* To whom correspondence should be addressed. Tel: +49 6221 387 372; Fax: +49 6221 387 517; Email: snel@embl-heidelberg.de


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