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Nucleic Acids Research, 2000, Vol. 28, No. 22 4474-4478
© 2000 Oxford University Press

Wild-derived inbred mouse strains have short telomeres

Michael T. Hemann1,2 and Carol W. Greider1,2,*

1Predoctoral Training Program in Human Genetics and 2Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Telomere length and telomerase activity directly affect the replicative capacity of primary human cells. Some have suggested that telomere length influences organismal lifespan. We compared telomere length distributions in a number of inbred and outbred established mouse strains with those of strains recently derived from wild mice. Telomere length was considerably shorter in wild-derived strains than in the established strains. We found no correlation of telomere length with lifespan, even among closely related inbred mouse strains. Thus, while telomere length plays a role in cellular lifespan in cultured human cells, it is not a major factor in determining organismal lifespan.

* To whom correspondence should be addressed at: Johns Hopkins University School of Medicine, 617 Hunterian Building, 725 North Wolfe Street, Baltimore, MD 21205, USA. Tel: +1 410 614 6506; Fax: +1 410 614 2987; Email: cgreider{at}jhmi.edu


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