Nucleic Acids Research, 2001, Vol. 29, No. 1 137-140
© 2001 Oxford University Press
RefSeq and LocusLink: NCBI gene-centered resources
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A Room 6N605, 8600 Rockville Pike, Bethesda, MD 20894 USA
Thousands of genes have been painstakingly identified and characterized a few genes at a time. Many thousands more are being predicted by large scale cDNA and genomic sequencing projects, with levels of evidence ranging from supporting mRNA sequence and comparative genomics to computing ab initio models. This, coupled with the burgeoning scientific literature, makes it critical to have a comprehensive directory for genes and reference sequences for key genomes. The NCBI provides two resources, LocusLink and RefSeq, to meet these needs. LocusLink organizes information around genes to generate a central hub for accessing gene-specific information for fruit fly, human, mouse, rat and zebrafish. RefSeq provides reference sequence standards for genomes, transcripts and proteins; human, mouse and rat mRNA RefSeqs, and their corresponding proteins, are discussed here. Together, RefSeq and LocusLink provide a non-redundant view of genes and other loci to support research on genes and gene families, variation, gene expression and genome annotation. Additional information about LocusLink and RefSeq is available at http://www.ncbi.nlm.nih.gov/LocusLink/.
* To whom correspondence should be addressed. Tel: +1 301 435 5898; Fax: +1 301 480 2290; Email: pruitt{at}ncbi.nlm.nih.gov
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W. Thompson, M. J. Palumbo, W. W. Wasserman, J. S. Liu, and C. E. Lawrence Decoding Human Regulatory Circuits Genome Res., October 1, 2004; 14(10a): 1967 - 1974. [Abstract] [Full Text] [PDF]
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T. S. Furey, M. Diekhans, Y. Lu, T. A. Graves, L. Oddy, J. Randall-Maher, L. W. Hillier, R. K. Wilson, and D. Haussler Analysis of Human mRNAs With the Reference Genome Sequence Reveals Potential Errors, Polymorphisms, and RNA Editing Genome Res., October 1, 2004; 14(10b): 2034 - 2040. [Abstract] [Full Text] [PDF]
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D. N. Messina, J. Glasscock, W. Gish, and M. Lovett An ORFeome-based Analysis of Human Transcription Factor Genes and the Construction of a Microarray to Interrogate Their Expression Genome Res., October 1, 2004; 14(10b): 2041 - 2047. [Abstract] [Full Text] [PDF]
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M. Oyama, C. Itagaki, H. Hata, Y. Suzuki, T. Izumi, T. Natsume, T. Isobe, and S. Sugano Analysis of Small Human Proteins Reveals the Translation of Upstream Open Reading Frames of mRNAs Genome Res., October 1, 2004; 14(10b): 2048 - 2052. [Abstract] [Full Text] [PDF]
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The MGC Project Team The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) Genome Res., October 1, 2004; 14(10b): 2121 - 2127. [Abstract] [Full Text] [PDF]
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B. Issac and G. P. S. Raghava EGPred: Prediction of Eukaryotic Genes Using Ab Initio Methods After Combining With Sequence Similarity Approaches Genome Res., September 1, 2004; 14(9): 1756 - 1766. [Abstract] [Full Text] [PDF]
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 E. Jamet Bioinformatics as a critical prerequisite to transcriptome and proteome studies J. Exp. Bot., September 1, 2004; 55(405): 1977 - 1979. [Abstract] [Full Text] [PDF]
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B. H. Mecham, D. Z. Wetmore, Z. Szallasi, Y. Sadovsky, I. Kohane, and T. J. Mariani Increased measurement accuracy for sequence-verified microarray probes Physiol Genomics, August 11, 2004; 18(3): 308 - 315. [Abstract] [Full Text] [PDF]
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J. Leipzig, P. Pevzner, and S. Heber The Alternative Splicing Gallery (ASG): bridging the gap between genome and transcriptome Nucleic Acids Res., August 3, 2004; 32(13): 3977 - 3983. [Abstract] [Full Text] [PDF]
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 R. H. Farkas, J. Qian, J. L. Goldberg, H. A. Quigley, and D. J. Zack Gene Expression Profiling of Purified Rat Retinal Ganglion Cells Invest. Ophthalmol. Vis. Sci., August 1, 2004; 45(8): 2503 - 2513. [Abstract] [Full Text] [PDF]
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G. Rajashekara, J. D. Glasner, D. A. Glover, and G. A. Splitter Comparative Whole-Genome Hybridization Reveals Genomic Islands in Brucella Species J. Bacteriol., August 1, 2004; 186(15): 5040 - 5051. [Abstract] [Full Text] [PDF]
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M. R. Nelson, G. Marnellos, S. Kammerer, C. R. Hoyal, M. M. Shi, C. R. Cantor, and A. Braun Large-Scale Validation of Single Nucleotide Polymorphisms in Gene Regions Genome Res., August 1, 2004; 14(8): 1664 - 1668. [Abstract] [Full Text] [PDF]
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P. C. FitzGerald, A. Shlyakhtenko, A. A. Mir, and C. Vinson Clustering of DNA Sequences in Human Promoters Genome Res., August 1, 2004; 14(8): 1562 - 1574. [Abstract] [Full Text] [PDF]
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P. M. Haverty, M. C. Frith, and Z. Weng CARRIE web service: automated transcriptional regulatory network inference and interactive analysis Nucleic Acids Res., July 1, 2004; 32(suppl_2): W213 - W216. [Abstract] [Full Text] [PDF]
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