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Nucleic Acids Research, 2001, Vol. 29, No. 1 210-213
© 2001 Oxford University Press

IMGT/HLA Database—a sequence database for the human major histocompatibility complex

James Robinson1, Matthew J. Waller1, Peter Parham3, Julia G. Bodmer4 and Steven G. E. Marsh1,2,*

1Anthony Nolan Research Institute and 2Department of Haematology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK, 3Departments of Structural Biology and Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA and 4Imperial Cancer Research Fund Cancer and Immunogenetics Laboratory, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK

The IMGT/HLA Database (www.ebi.ac.uk/imgt/hla/) specialises in sequences of polymorphic genes of the HLA system, the human major histocompatibility complex (MHC). The HLA complex is located within the 6p21.3 region on the short arm of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and these include the 21 highly polymorphic HLA genes, which influence the outcome of clinical transplantation and confer susceptibility to a wide range of non-infectious diseases. The database contains sequences for all HLA alleles officially recognised by the WHO Nomenclature Committee for Factors of the HLA System and provides users with online tools and facilities for their retrieval and analysis. These include allele reports, alignment tools and detailed descriptions of the source cells. The online IMGT/HLA submission tool allows both new and confirmatory sequences to be submitted directly to the WHO Nomenclature Committee. The latest version (release 1.7.0 July 2000) contains 1220 HLA alleles derived from over 2700 component sequences from the EMBL/GenBank/DDBJ databases. The HLA database provides a model which will be extended to provide specialist databases for polymorphic MHC genes of other species.

* To whom correspondence should be addressed. Tel: +44 20 7284 8321; Fax: +44 20 7284 8331; Email: marsh{at}ebi.ac.uk


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