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Nucleic Acids Research, 2001, Vol. 29, No. 1 260-263
© 2001 Oxford University Press

AsMamDB: an alternative splice database of mammals

Hongkai Ji*, Qing Zhou, Fang Wen, Huiyu Xia, Xin Lu and Yanda Li

Institute of Bioinformatics, Tsinghua University, Beijing, 100084, China

The objective of database AsMamDB is to facilitate the systematic study of alternatively spliced genes of mammals. Version 1.0 of AsMamDB contains 1563 alternatively spliced genes of human, mouse and rat, each associated with a cluster of nucleotide sequences. The main information provided by AsMamDB includes gene alternative splicing patterns, gene structures, locations in chromosomes, products of genes and tissues where they express. Alternative splicing patterns are represented by multiple alignments of various gene transcripts and by graphs of their topological structures. Gene structures are illustrated by exon, intron and various regulatory elements distributions. There are 4204 DNAs, 3977 mRNAs, 8989 CDSs and 126 931 ESTs in the current database. More than 130 000 GenBank entries are covered and 4443 MEDLINE records are linked. DNA, mRNA, exon, intron and relevant regulatory element sequences are provided in FASTA format. More information can be obtained by using the web-based multiple alignment tool Asalign and various category lists. AsMamDB can be accessed at http://166.111.30.65/ASMAMDB.html .

* To whom correspondence should be addressed. Tel: +86 10 627 82877; Fax: +86 10 627 72237; Email: jihk99{at}mails.tsinghua.edu.cn The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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