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Nucleic Acids Research, 2002, Vol. 30, No. 1 163-165
© 2002 Oxford University Press

PharmGKB: the Pharmacogenetics Knowledge Base

Micheal Hewett*, Diane E. Oliver, Daniel L. Rubin, Katrina L. Easton, Joshua M. Stuart, Russ B. Altman and Teri E. Klein

Stanford Medical Informatics, 251 Campus Drive, MSOB X-215, Stanford, CA 94305-5479, USA

The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.

* To whom correspondence should be addressed. Tel: +1 650 736 0653; Fax: +1 650 725 7944; Email: hewett@smi.stanford.edu


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