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Nucleic Acids Research, 2002, Vol. 30, No. 1 214-217
© 2002 Oxford University Press

HugeIndex: a database with visualization tools for high-density oligonucleotide array data from normal human tissues

Peter M. Haverty1, Zhiping Weng1,2,*, Nathan L. Best3, Kenneth R. Auerbach3, Li-Li Hsiao3, Roderick V. Jensen4 and Steven R. Gullans3

1Bioinformatics Program and 2Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02115, USA, 3Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA and 4Department of Physics, Wesleyan University, Middletown, CT, USA

High-density oligonucleotide arrays are a powerful tool for uncovering changes in global gene expression in various disease states. To this end, it is essential to first characterize the variations of gene expression in normal physiological processes. We established the Human Gene Expression (HuGE) Index database (www.HugeIndex.org) to serve as a public repository for gene expression data on normal human tissues using high-density oligonucleotide arrays. This resource currently contains the results of 59 gene expression experiments on 19 human tissues. We provide interactive tools for researchers to query and visualize our data over the Internet. To facilitate data analysis, we cross-reference each gene on the array with its annotation in the LocusLink database at NCBI.

* To whom correspondence should be addressed at: Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02115, USA. Tel: +1 617 353 3509; Fax: +1 617 353 6766; Email: zhiping{at}bu.edu Correspondence may also be addressed to Steven R. Gullans. Tel: +1 617 525 5712; Fax: +1 617 525 5711; Email: sgullans{at}rics.bwh.harvard.edu


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