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Nucleic Acids Research, 2002, Vol. 30, No. 1 335-340
© 2002 Oxford University Press

UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002

Graziano Pesole*, Sabino Liuni1, Giorgio Grillo1, Flavio Licciulli2, Flavio Mignone, Carmela Gissi and Cecilia Saccone2

Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, 20133 Milano, Italy, 1Centro di Studio sui Mitocondri e Metabolismo Energetico del Consiglio Nazionale delle Ricerche (CNR), via Amendola 165/A, 70126 Bari, Italy and 2Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, via Orabona 4, 70126 Bari, Italy

The 5'- and 3'-untranslated regions (5'- and 3'-UTRs) of eukaryotic mRNAs are known to play a crucial role in post-transcriptional regulation of gene expression modulating nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and stability. UTRdb is a specialized database of 5' and 3' untranslated sequences of eukaryotic mRNAs cleaned from redundancy. UTRdb entries are enriched with specialized information not present in the primary databases including the presence of nucleotide sequence patterns already demonstrated by experimental analysis to have some functional role. All these patterns have been collected in the UTRsite database so that it is possible to search any input sequence for the presence of annotated functional motifs. Furthermore, UTRdb entries have been annotated for the presence of repetitive elements. All Internet resources we implemented for retrieval and functional analysis of 5'- and 3'-UTRs of eukaryotic mRNAs are accessible at http://bighost.area.ba.cnr.it/BIG/UTRHome/.

* To whom correspondence should be addressed. Tel: +39 02 58354915; Fax +39 02 58354912; Email: graziano.pesole{at}unimi.it


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