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Nucleic Acids Research, 2002, Vol. 30, No. 11 2307-2315
© 2002 Oxford University Press

Tiny telomere DNA

Jinsong Ren, Xiaogang Qu, John O. Trent1 and Jonathan B. Chaires*

Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA and 1J. G. Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, USA

We describe the design, synthesis and biophysical characterization of a novel DNA construct in which a folded quadruplex structure is joined to a standard double helix. Circular dichroism, gel electrophoresis, three-dimensional UV melting and differential scanning calorimetry were all used to characterize the structure. Rigorous molecular dynamics simulations were used to build a plausible atomic-level structural model of the DNA construct. This novel DNA construct provides a model for the duplex–quadruplex junction region at the end of chromosomal DNA and offers a system for the study of structure-selective ligand binding.

* To whom correspondence should be addressed. Tel: +1 601 984 1523; Fax: +1 601 815 1171; Email: jchaires{at}biochem.umsmed.edu Correspondence may also be addressed to John O. Trent. Tel: +1 502 852 2196; Fax: +1 502 852 2195; Email: jotren01{at}gwise.louisville.edu


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