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Nucleic Acids Research, 2002, Vol. 30, No. 13 3005-3014
© 2002 Oxford University Press

Studies on the synthesis of a G-rich octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 by the phosphotriester approach and its formation of G-quartet structure

Jun Chen, Liang Ren Zhang, Ji Mei Min and Li He Zhang*

National Research Laboratory of Natural and Biomimetic Drugs, Peking University, 38 Xueyuan Road, Beijing 100083, People’s Republic of China

The octaoligoisonucleotide (isoT)2(isoG)4(isoT)2 (I), consisting of isonucleoside units 6'-O-allyl-4'-deoxy-4'-(nucleobase)-2',5'-anhydro-L-mannitol, was synthesized by the phosphotriester approach in solution phase. Based on CD spectra and capillary electrophoresis, it was confirmed that iso-oligomer I could form a parallel intermolecular G-quadruplex structure. K+, Na+ and Li+ can prompt the formation of G-quartet structures and stabilize them. The effective order of these cations is K+ > Na+ > Li+.

* To whom correspondence should be addressed. Tel: +86 10 6209 1700; Fax: +86 10 6209 2724; Email: zdszlh{at}mail.bjmu.edu.cn


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