Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (178K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Chong, S.
Right arrow Articles by Bonifer, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chong, S.
Right arrow Articles by Bonifer, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 2002, Vol. 30, No. 2 463-467
© 2002 Oxford University Press

The chicken lysozyme chromatin domain contains a second, widely expressed gene

Suyinn Chong, Arthur D. Riggs and Constanze Bonifer1,*

Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA and 1Molecular Medicine Unit, St James’ University Hospital, University of Leeds, Leeds LS9 7TF, UK

The chicken lysozyme (cLys) locus has been shown to contain all of the cis-elements necessary for position-independent and tissue-specific expression entirely within a 24-kb region defined by general DNase I sensitivity and flanked by matrix attachment regions. As such, it has been viewed as an example of a functional chromatin domain, which is structurally and functionally isolated from neighbouring chromatin. We report here the identification and characterisation of the chicken glioma-amplified sequence (cGas41) locus, which though widely expressed, is contained entirely within the lysozyme chromatin domain. The cGas41 transcript encodes a putative transcription factor, starts 207 bp downstream of the cLys polyadenylation site and is preceded by a CpG island with proposed dual promoter/origin function. The location and differential expression of cGas41 compels re-evaluation of the accumulated literature on the lysozyme domain, and represents an example of two unrelated, differentially expressed vertebrate genes coexisting in the same functional chromatin domain.

* To whom correspondence should be addressed. Tel: +44 113 206 5676; Fax: +44 113 244 4475; Email: c.bonifer{at}leeds.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
F. A. Myers, P. Lefevre, E. Mantouvalou, K. Bruce, C. Lacroix, C. Bonifer, A. W. Thorne, and C. Crane-Robinson
Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements
Nucleic Acids Res., September 1, 2006; 34(14): 4025 - 4035.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
K. Bruce, F. A. Myers, E. Mantouvalou, P. Lefevre, I. Greaves, C. Bonifer, D. J. Tremethick, A. W. Thorne, and C. Crane-Robinson
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken
Nucleic Acids Res., October 4, 2005; 33(17): 5633 - 5639.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Lefevre, C. Lacroix, H. Tagoh, M. Hoogenkamp, S. Melnik, R. Ingram, and C. Bonifer
Differentiation-dependent Alterations in Histone Methylation and Chromatin Architecture at the Inducible Chicken Lysozyme Gene
J. Biol. Chem., July 29, 2005; 280(30): 27552 - 27560.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Braas, H. Gundelach, and K.-H. Klempnauer
The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene
Nucleic Acids Res., September 8, 2004; 32(16): 4750 - 4757.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Tagoh, S. Melnik, P. Lefevre, S. Chong, A. D. Riggs, and C. Bonifer
Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro
Blood, April 15, 2004; 103(8): 2950 - 2955.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. J. Mullins and J. J. Mullins
Large transgenes reveal their secrets. Focus on "Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice"
Physiol Genomics, March 12, 2004; 17(1): 1 - 3.
[Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
R. Nistala, X. Zhang, and C. D. Sigmund
Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice
Physiol Genomics, March 12, 2004; 17(1): 4 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Giraldo, A. Martinez, L. Regales, A. Lavado, A. Garcia-Diaz, A. Alonso, A. Busturia, and L. Montoliu
Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity
Nucleic Acids Res., November 1, 2003; 31(21): 6290 - 6305.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. A. Myers, W. Chong, D. R. Evans, A. W. Thorne, and C. Crane-Robinson
Acetylation of Histone H2B Mirrors that of H4 and H3 at the Chicken {beta}-Globin Locus but Not at Housekeeping Genes
J. Biol. Chem., September 19, 2003; 278(38): 36315 - 36322.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.