Nucleic Acids Research, 2002, Vol. 30, No. 20 4432-4441
© 2002 Oxford University Press
Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157
1 State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China, 2 Laboratory of Molecular Virology, Fudan University, Shanghai 200032, China, 3 Institute of Epidemiology and Microbiology, Chinese Academy of Preventive Medicine, Beijing 102206, China, 4 Peking University Health Science Center, Beijing 100083, China, 5 National Center of Human Genome Research, Beijing 100176, China, 6 Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, 7 Microbial Genome Center, Chinese Ministry of Public Health, Beijing 100052, China, 8 Beijing Microbial Genome Research Center, Beijing 100052, China, 9 HuaBei Pharmaceutical Co., Ltd, Shijiazhuang 0500, China and 10 Molecular Infectious Diseases Group, Department of Paediatrics Faculty of Medicine, Imperial College St Mary’s Campus, London W2 1PG, UK
*To whom correspondence should be addressed. Tel: +86 10 67877732; Fax: +86 10 67877736; Email: zdsys{at}sina.com
We have sequenced the genome of Shigella flexneri serotype 2a, the most prevalent species and serotype that causes bacillary dysentery or shigellosis in man. The whole genome is composed of a 4 607 203 bp chromosome and a 221 618 bp virulence plasmid, designated pCP301. While the plasmid shows minor divergence from that sequenced in serotype 5a, striking characteristics of the chromosome have been revealed. The S.flexneri chromosome has, astonishingly, 314 IS elements, more than 7-fold over those possessed by its close relatives, the non-pathogenic K12 strain and enterohemorrhagic O157:H7 strain of Escherichia coli. There are 13 translocations and inversions compared with the E.coli sequences, all involve a segment larger than 5 kb, and most are associated with deletions or acquired DNA sequences, of which several are likely to be bacteriophage-transmitted pathogenicity islands. Furthermore, S.flexneri, resembling another human-restricted enteric pathogen, Salmonella typhi, also has hundreds of pseudogenes compared with the E.coli strains. All of these could be subjected to investigations towards novel preventative and treatment strategies against shigellosis.
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|
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|
|
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|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
H.-Y. Ou, L.-L. Chen, J. Lonnen, R. R. Chaudhuri, A. B. Thani, R. Smith, N. J. Garton, J. Hinton, M. Pallen, M. R. Barer, et al. A novel strategy for the identification of genomic islands by comparative analysis of the contents and contexts of tRNA sites in closely related bacteria Nucleic Acids Res., January 9, 2006; 34(1): e3 - e3. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
F. Yang, J. Yang, X. Zhang, L. Chen, Y. Jiang, Y. Yan, X. Tang, J. Wang, Z. Xiong, J. Dong, et al. Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery Nucleic Acids Res., November 7, 2005; 33(19): 6445 - 6458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C. Neylon, A. V. Kralicek, T. M. Hill, and N. E. Dixon Replication Termination in Escherichia coli: Structure and Antihelicase Activity of the Tus-Ter Complex Microbiol. Mol. Biol. Rev., September 1, 2005; 69(3): 501 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ochman Genomes on the shrink PNAS, August 23, 2005; 102(34): 11959 - 11960. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
B. Li, E. W. Brown, C. D'Agostino, J. E. LeClerc, and T. A. Cebula Structure and distribution of the phosphoprotein phosphatase genes, prpA and prpB, among Shigella subgroups Microbiology, August 1, 2005; 151(8): 2671 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
E. Belda, A. Moya, and F. J. Silva Genome Rearrangement Distances and Gene Order Phylogeny in {gamma}-Proteobacteria Mol. Biol. Evol., June 1, 2005; 22(6): 1456 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
D. Mokady, U. Gophna, and E. Z. Ron Extensive Gene Diversity in Septicemic Escherichia coli Strains J. Clin. Microbiol., January 1, 2005; 43(1): 66 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
M. D. Winfield and E. A. Groisman Phenotypic differences between Salmonella and Escherichia coli resulting from the disparate regulation of homologous genes PNAS, December 7, 2004; 101(49): 17162 - 17167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
N. A. Kaniuk, E. Vinogradov, J. Li, M. A. Monteiro, and C. Whitfield Chromosomal and Plasmid-encoded Enzymes Are Required for Assembly of the R3-type Core Oligosaccharide in the Lipopolysaccharide of Escherichia coli O157:H7 J. Biol. Chem., July 23, 2004; 279(30): 31237 - 31250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
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M. Casalino, M. C. Latella, G. Prosseda, and B. Colonna CadC Is the Preferential Target of a Convergent Evolution Driving Enteroinvasive Escherichia coli toward a Lysine Decarboxylase-Defective Phenotype Infect. Immun., October 1, 2003; 71(10): 5472 - 5479. [Abstract] [Full Text] [PDF]
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R. Sturny, K. Cam, C. Gutierrez, and A. Conter NhaR and RcsB Independently Regulate the osmCp1 Promoter of Escherichia coli at Overlapping Regulatory Sites J. Bacteriol., August 1, 2003; 185(15): 4298 - 4304. [Abstract] [Full Text] [PDF]
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L. Florea, M. McClelland, C. Riemer, S. Schwartz, and W. Miller EnteriX 2003: visualization tools for genome alignments of Enterobacteriaceae Nucleic Acids Res., July 1, 2003; 31(13): 3527 - 3532. [Abstract] [Full Text] [PDF]
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C. Canchaya, C. Proux, G. Fournous, A. Bruttin, and H. Brussow Prophage Genomics Microbiol. Mol. Biol. Rev., June 1, 2003; 67(2): 238 - 276. [Abstract] [Full Text] [PDF]
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J. Wei, M. B. Goldberg, V. Burland, M. M. Venkatesan, W. Deng, G. Fournier, G. F. Mayhew, G. Plunkett III, D. J. Rose, A. Darling, et al. Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T Infect. Immun., May 1, 2003; 71(5): 2775 - 2786. [Abstract] [Full Text] [PDF]
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D. J. Studholme and R. Dixon Domain Architectures of {sigma}54-Dependent Transcriptional Activators J. Bacteriol., March 15, 2003; 185(6): 1757 - 1767. [Full Text] [PDF]
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