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Nucleic Acids Research, 2002, Vol. 30, No. 5 1124-1131
© 2002 Oxford University Press

Chemical incorporation of 1-methyladenosine into oligonucleotides

Sergey N. Mikhailov, Jef Rozenski, Ekaterina V. Efimtseva, Roger Busson, Arthur Van Aerschot and Piet Herdewijn*

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

The base moiety of 1-N-methyladenosine can be protected with a chloroacetyl group for incorporation of this modified nucleoside into DNA and RNA. Carefully controlled anhydrous conditions are needed for deprotection of the oligonucleotides.

* To whom correspondence should be addressed. Tel: +32 16 337487; Fax: +32 16 337340; Email: piet.herdewijn{at}rega.kuleuven.ac.be


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