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Nucleic Acids Research, 2003, Vol. 31, No. 1 237-240
© 2003 Oxford University Press

WorfDB: the Caenorhabditis elegans ORFeome Database

Philippe Vaglio*, Philippe Lamesch, Jérôme Reboul, Jean-François Rual, Monica Martinez, David Hill and Marc Vidal

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Harvard Medical School, Smith 858, 1 Jimmy Fund Way, Boston, MA 02115, USA

*To whom correspondence should be addressed. Email: philippe_vaglio{at}dfci.harvard.edu
Correspondence may also be addressed to Marc Vidal. Email: marc_vidal{at}dfci.harvard.edu

ABSTRACT

WorfDB (Worm ORFeome DataBase; http://worfdb.dfci.harvard.edu) was created to integrate and disseminate the data from the cloning of complete set of ~19 000 predicted protein-encoding Open Reading Frames (ORFs) of Caenorhabditis elegans (also referred to as the ‘worm ORFeome’). WorfDB serves as a central data repository enabling the scientific community to search for availability and quality of cloned ORFs. So far, ORF sequence tags (OSTs) obtained for all individual clones have allowed exon structure corrections for ~3400 ORFs originally predicted by the C. elegans sequencing consortium. In addition, we now have OSTs for ~4300 predicted genes for which no ESTs were available. The database contains this OST information along with data pertinent to the cloning process. WorfDB could serve as a model database for other metazoan ORFeome cloning projects.


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