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Nucleic Acids Research, 2003, Vol. 31, No. 1 251-254
© 2003 Oxford University Press

InterDom: a database of putative interacting protein domains for validating predicted protein interactions and complexes

See-Kiong Ng*, Zhuo Zhang, Soon-Heng Tan and Kui Lin1

Biocomputing Group, Laboratories for Information Technology, 21 Heng Mui Keng Terrace, 119613 Singapore 1 Genome Institute of Singapore, 1 Science Park Road, #05-01, 117528 Singapore

*To whom correspondence should be addressed. Tel: +65 68746596; Fax: +65 67748056; Email: skng{at}lit.a-star.edu.sg

ABSTRACT

Advances in proteomics technology have enabled new proteins to be discovered at an unprecedented speed, and high throughput experimental methods have been developed to detect protein interactions and complexes en masse. Such bottom-up, data-driven approach has resulted in data that may be uninformative or potentially errorful, requiring further validation and annotation. The InterDom database focuses on providing supporting evidence for the detected protein interactions based on putative protein domain interactions. Using an integrative approach, InterDom derives potential domain interactions by combining data from multiple sources, ranging from domain fusions, protein interactions and complexes, to scientific literature. The InterDom database is available at http://InterDom.lit.org.sg.


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